Despite worldwide attention, work-related musculoskeletal disorders (MSDs) remain a substantial concern at work, and result in considerable personal and societal burden. Information from a recent survey indicates that a minority of workplaces are taking action. Identifying hazards and performing risk assessments are key steps in workplace prevention activities. Do workplaces have the tools and training to do this? In order to then perform intense MSD prevention activities, interventions need to address important risk factors for a large proportion of exposed workers. The presentation explores these challenges.