Breast cancer and shift work: mechanisms and measurement

Institute for Work & Health
481 University Avenue, Suite 800
Toronto, Ontario

Lin Fritschi
Western Australian Institute for Medical Research in Perth, Western Australia

In 2007, based on good evidence from mouse studies and limited evidence from epidemiological studies, IARC declared that shift work involving night work was a probable carcinogen (mainly regarding breast cancer). Since then, several studies on shift work and breast cancer have been released, which are less supportive of the association. In the epidemiological literature, the dominant hypothesis regarding the underlying mechanism for the association is that light at night suppresses melatonin, resulting in a diminution of the anti-carcinogenic effects.

In this talk, Lin Fritschi, cancer epidemiologist and head of the Epidemiology Group at the Western Australian Institute for Medical Research in Perth, will outline the framework that includes an additional four possible mechanisms. This framework has been used to design a questionnaire that can disentangle various aspects of shift work, in order to determine which of the mechanisms are most related to any effect. Fritschi's group is using this questionnaire in a current case-control study of breast cancer.

About IWH Speaker Series

The IWH Speaker Series brings you the latest findings from work and health researchers from the Institute for Work & Health (IWH) and other Canadian and international academic institutions around the world. For those unable to attend in person or via live stream, most presentations in the IWH Speaker Series are audio-recorded and made available as slidecasts, typically within two weeks of the original presentation.