Interventions to prevent work disability can vary widely. They can include: changes in laws and regulations; provider training and education; outreach and support to workers and supervisors; modified employer policies and practices; and changes in insurance and medical reimbursement policies. Given the very wide band of possible strategies in this area, researchers and policy makers face some serious design challenges when developing feasible and effective interventions. In this presentation, Dr. Bill Shaw discusses three intervention design issues: reach, implementation, and organizational structure. He draws on published and ongoing studies to discuss feasibility constraints, design assumptions and evaluation methods.